For all manuscripts, authors must indicate in a cover letter:

· Title of article;

· Name(s) of all author(s);

· Adress, telephone number, fax, and e-mail of the corresponding author;

· A statement signed by the corresponding author confirming that the content of the manuscript represents the views of the co-authors, that neither the corresponding author nor the co-authors have submitted duplicate or overlapping manuscripts elsewhere, and that the items indicated as personal communications in the text are supported by the referenced person;

· The registration number of all randomised controlled trials and clinical trials, in accordance with the International Committee of Medical Journal Editors;

· In the same case, the corresponding author have to send a statement indicating that written informed consent was obtained from all participants;

· All original articles should indicate the number of the Ethics Committee approval. If the article do not need an approval of the Ethics Committe, the author should write it separately in the article;

· Animal experimentation should be carried out according to institutional guidelines for experimental use of animals;

· The authors should obtain written permission to reproduce figures and tables from other sources;

· If the study was supported by any institution, it has to be indicated in the cover letter.

The cover letter should be in one double-spaced electronic document, title (no more than eight words in the title; no more than five authors may be listed, including name, highest academic degree, address, email address, telephone and fax number of each author; the text should contain no more than 300 words.

Supplements to the BJID include articles under a unifying theme, such as those summarizing presentations of symposia or fosucing on a specific pathogenic process or antimicrobial agent. These will be added to the regular bi-monthly publication as appropriate, and will be peer reviewed in the same manner as submitted manuscripts.

Each manuscript will be assigned a registration number, and the author notified that the manuscript is complete and appropriate to begin the review process.

Contributions should be double-spaced and written in English or Portuguese (see item Translation). All manuscripts are to be typed double-spaced, including text, tables, references and legends; the character should be Time New Roman for all text, including figures, graphics and tables, or Symbol for Greek character; size 12 should be used in all manuscript. All pages are to be numbered, with the order of presentation as follows: title page, abstract, text, acknowledgements, references, tables, figure legends and figures. The manuscripts have to be saved in Word document and the figures should be saved in CorelDraw, JPG or TIF document with high resolution - minimum of 300 dpi).

· Titles should be in bold;

· Subtitles should be in underscore;

· Titles do not have abbreviations or acronyms;

· Titles do not exceed two printed lines;

· Do not exceed 80 characters (inc. spaces)

· Complete name of the authors (do not abbreviate);

· Affiliations of all authors, including high degree and institution(s);

· Name, mailing addresses, phone and fax number, e-mail, state, city and country of the corresponding author;

· Acknowledgment of research grants and fellowships (agency and grant number).

· All manuscripts, except Clinical Infectious Diseases Images, Letters and Editorials, have to indicate a running title.

· Do not exceed 40 characters (inc. spaces).

· Insert the head running at the top of the page.

· Consider the manuscript formats to verify the number of key words;

· Use capital letter for the first word, the other should be in regular form.

· The abstract should briefly contain the objective, data, methods, results and discussion of the study or presentation to allow the reader an understanding of the manuscript;

· Do not use abbreviations in abstract;

· Do not use references in abstract;

· Consider the manuscript formats to verify the number of words.

In the text of Introduction the authors have to reveal the aim of the study, the purpose of the research, and the basic literature about the subject.

· This section should be subdivided by short underscore headings referring to methods used;

· This section cannot contain figures or tables;

· The material and methods used have to be described very carefully to permit repeat the study and to determine if the results were possible and right;

· Papers with statistical testing should state the name of the test, the n for each analysis, the comparisons of interest, a justification of that test, the alpha level for all tests, whether the tests were one- or two- tailes, and the actual P value for each test;

· Data sets should be summarized with descriptive statistics, which should include the n for each data set, a clearly labelled measure of centre (such as the mean or the median), and a clearly labelled measure of variability (such as the standard deviation or range).

· The data of the results should be described concisely;

· Tables, graphics and figures have to be inserted in this section;

· The data presented in this section have to be oriented by universal units.

· Tables should be clear enough to the authors do not need the text to understand them;

· Tables and figures should be presented on separate pages, portrait orientation and Tables

· Tables should be clear enough to the readers do not need the text to understand them;

· Tables should be presented on separate pages, portrait orientation, and upright on the page;

· Tables have to be a short one-line title in bold;

· Tables have to be numbered consecutively with Arabic numerals in the text;

· Symbols and abbreviations are defined immediately below the table;

· Other informations about the table have to be below the symbols and abbreviations;

· If the table is from another source, the authors must indicate the source and send the permission to the Journal.

· Figure legend should be listed one after the other, as a part of the text document, separate from the figure files, with a short one-line title in bold.

· Figures should be submitted in paper or in CDR, TIF, JPG file (300 dpi) or presented in glossy photographs or as high-quality laser prints on bond paper;

· Figures should be clear enough to the readers do not need the text to understand them;

· Figures should be presented on separate pages, portrait orientation, and upright on the page;

· Figures have to be numbered consecutively with Arabic numerals in the text;

· Symbols and abbreviations are defined immediately below the figure, as well as any other informations about the figures;

· If the figure is from another source, the authors must indicate the source and send the permission to the Journal.

The discussion presents the results comparing and evaluating them with literature and the existing knowledge. References with other studies should appear in the Discussion to compare the data obtained in the methods and results of the paper.

In this section the authors confirms or not their interpretation presented in Discussion with the existing literature. In this section the authors recommend if it is important more data, if the study is a innovative point of view of a subject, or if the study confirms the knowledgemets about the subject.

The authors could thank anyone help them to do the paper or the study.

The authors must indicate in the cover letter if the study was supported by an institutions.

Footnotes should be numbered consecutively and must appear superscripted and in Arabic number in the text; and their information has to be informed at the bottom of the page they appeared.

· All abbreviations have to be explained in the text, figure and table legends when they first appear;

· Include the abbreviation in parenthesis after they first appearence.

· Do not abbreviate units [(5 mL, not 5 milliliters (mL)];

· Do not abbreviate institutions;

· Abbreviations must follow the format of the National Library of Medicine (USA) as in Index Medicus.

· Follow the use of the The Système International (SI) (http://physics.nist.gov/cuu/Units).

References should be listed consecutively in the text and recorded as follows in the reference list. Authors (when fewer than five, record all authors; when five or more, record first three followed by et al.), title, journal, year, volume, pages (first and last). The year of the references must be in bold. References must follow the format of the National Library of Medicine as in Index Medicus. Titles of journals not listed in Index Medicus should be spelled out in full. Several examples of specific references follow:

If the journal is not listed in Index Medicus - Smith J.C., Charles R.S. Microbes and water filters. Journal of Water Purification 1996;20:165-170.

If the journal is in Index Medicus - Watson B.M., Gupta R., Randal T., Starr S. Persistence of cell-mediated immune responses post-VZV immunization. J Infect Dis 1994;169:197-9.

Taylor D.M., Personnet J. Epidemiology and natural history of Helicobacter pylori infection. In: Blaser M.J., Smith P.D., Ravdin J. eds. Infections of the gastrointestinal tract. New York: Raven Press, 1994.

Polak J.M., Van Noordan S. An introduction to immunochemistry: current techniques and problems.

Oxford, UK: Oxford University Press, 1987.

Blatt S.P., Butzin C.A., Lucey D.R., Melcher G.P., Hendrix C.R. Anergy status and CD4 CD29 memory

T-cells predict progression to AIDS (abstract PoB 3480). In: Program and abstracts: VIII International

Conference on AIDS (Amsterdam) Amsterdam: CONGREX Holland, 1992.